What is the primary therapeutic use of sildenafil?

Sildenafil is primarily used for treating erectile dysfunction, which is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. The mechanism of action involves the inhibition of phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) and resulting vascular dilation in the corpus cavernosum of the penis. This process enhances blood flow, facilitating an erection in response to sexual stimulation.

While sildenafil's ability to cause vasodilation has led to explorations of its use in other conditions, such as pulmonary hypertension, its most recognized and primary therapeutic use remains in the management of erectile dysfunction. Other choices, such as managing chronic pain or reducing anxiety levels, do not align with the pharmacological effects of sildenafil, as it is not indicated or effective for these conditions.