Which of the following is a contraindication for the use of ceftriaxone?

Ceftriaxone is a broad-spectrum cephalosporin antibiotic commonly used to treat various infections. However, it has specific contraindications that must be taken into account when prescribing it.

In patients with a history of jaundice, particularly those with a liver disorder or impaired hepatic function, the use of ceftriaxone can lead to serious complications. Ceftriaxone is known to displace bilirubin from its binding sites on albumin, which can exacerbate hyperbilirubinemia in susceptible individuals, especially in neonates. Elevated levels of bilirubin can lead to kernicterus, a form of brain damage due to excessive bilirubin in the bloodstream.

In contrast, urinary tract infections are a common indication for ceftriaxone, diabetic patients generally do not have specific contraindications for its use, and while caution is advised during pregnancy, ceftriaxone may still be utilized if the benefits outweigh the risks as it falls into category B for pregnancy safety, indicating that animal studies have not shown a risk to the fetus.

Thus, considering these factors, a history of jaundice stands out as a clear contraindication for ceftriaxone use due to the potential for serious adverse effects on bilirubin metabolism and the associated