Which ophthalmic solution should be avoided in clients diagnosed with glaucoma?

Atropine is an anticholinergic medication that causes pupil dilation (mydriasis) by blocking the action of acetylcholine on the iris sphincter muscle. In clients diagnosed with glaucoma, particularly those with angle-closure glaucoma, the use of atropine can exacerbate the condition. This is because the dilation of the pupil can lead to an increase in intraocular pressure by blocking the drainage of aqueous humor through the trabecular meshwork, ultimately worsening the patient's glaucomatous condition.

In contrast, medications like timolol, pilocarpine, and epinephrine have mechanisms that can help in managing glaucoma. Timolol is a non-selective beta-blocker that reduces aqueous humor production. Pilocarpine is a cholinergic agonist that increases aqueous humor outflow, which can be beneficial in reducing intraocular pressure. Epinephrine, while more commonly used in certain contexts, can also assist in lowering intraocular pressure through various mechanisms. Thus, patients with glaucoma should avoid atropine due to its potential to increase intraocular pressure and worsen their condition.