Why is vitamin B6 given with isoniazid during tuberculosis treatment?

Vitamin B6, also known as pyridoxine, is administered alongside isoniazid primarily because isoniazid can lead to a deficiency of this vitamin. Isoniazid is known to inhibit the enzyme that is involved in the metabolism of pyridoxine, which can result in inadequate levels of vitamin B6 in the body. This deficiency can potentially lead to neuropathies and adverse effects, including peripheral neuropathy, which is particularly concerning in patients undergoing treatment for tuberculosis.

By providing vitamin B6 supplementation, healthcare professionals can help mitigate these side effects and maintain normal functioning of the nervous system during treatment with isoniazid. It's important to ensure that patients remain as comfortable and healthy as possible as they undergo potentially lengthy tuberculosis therapy.